G359 – Special single agent or multi-agent therapy

Special single agent or multi-agent therapy – chemotherapy and/or biologic agent(s) with major toxicity that require frequent monitoring and prolonged administration periods and may require immediate intervention by the physician. General Chemotherapy Requirements: This service is for the pharmacologic therapy of malignancy or autoimmune disease, with administration supervised by a physician for intravenous infusion. The physician must be available to intervene in a timely fashion at the initiation and for the duration of the prescribed therapy to manage immediate and delayed toxicities. The fee for chemotherapy and patient assessment provided by a physician includes all patient assessments by any physician for a 24 hour period following treatment administration. [Commentary from Schedule] Examples of special agent therapy include: - high-dose methotrexate with folinic acid rescue - methotrexate given in a dose of greater than 1 g/m2 - high dose cisplatin greater than 75 mg/m2 given concurrently with hydration and osmotic diuresis - high dose cystosine, arabinoside (greater than 2 g/m2) - high dose cyclophosphamide (greater than 1 g/m2) - ifosfamide with MESNA protection - combination of biologic agents with complex chemotherapy.