What is OHIP billing code G359?

G359 is "Special single agent or multi-agent therapy", an OHIP Diagnostic and Therapeutic Procedures code from the Ontario Schedule of Benefits (Physician Services).

How much does G359 pay?

The current OHIP fee for G359 is $105.15, effective 2025-04-01, per the Ontario Schedule of Benefits.

How do I bill G359 to OHIP?

G359 is submitted through OHIP's MCEDT claims system, either directly or via billing software. SnapBill validates G359 claims against the Schedule of Benefits rules before submission.

What codes are related to G359?

Codes related to G359 in the Schedule of Benefits include G381, G281, G345, G075, G390.

All codes

G359

G359 – Special single agent or multi-agent therapy

OHIP Diagnostic and Therapeutic Procedures Code — DIAGNOSTIC AND THERAPEUTIC PROCEDURES · Schedule of Benefits

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Special single agent or multi-agent therapy – chemotherapy and/or biologic agent(s) with major toxicity that require frequent monitoring and prolonged administration periods and may require immediate intervention by the physician. General Chemotherapy Requirements: This service is for the pharmacologic therapy of malignancy or autoimmune disease, with administration supervised by a physician for intravenous infusion. The physician must be available to intervene in a timely fashion at the initiation and for the duration of the prescribed therapy to manage immediate and delayed toxicities. The fee for chemotherapy and patient assessment provided by a physician includes all patient assessments by any physician for a 24 hour period following treatment administration. [Commentary from Schedule] Examples of special agent therapy include: • high-dose methotrexate with folinic acid rescue • methotrexate given in a dose of greater than 1 g/m2 • high dose cisplatin greater than 75 mg/m2 given concurrently with hydration and osmotic diuresis • high dose cystosine, arabinoside (greater than 2 g/m2) • high dose cyclophosphamide (greater than 1 g/m2) • ifosfamide with MESNA protection • combination of biologic agents with complex chemotherapy.

G381 G281 G345 G075 G390

G381, G345 and G359 are only eligible for payment with respect to the following classes of biologic agents: a. monoclonal antibodies; and b. cytokines.

G381, G345, G359, G075 and G390 include venipuncture, establishment of any vascular access line and administration of agent(s).

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