G388 – Management of special oral chemotherapy
OHIP Diagnostic & Therapeutic Procedures Code — DIAGNOSTIC AND THERAPEUTIC PROCEDURES · Schedule of Benefits
This is the service for the supervision of oral chemotherapy treatment for malignant disease where the agent(s) has a significant risk of toxicity in the period immediately following initiation. The physician must be available to intervene in a timely fashion for a 24 hour period following the initiation of the treatment. In addition to the Common Elements in this Schedule, this service includes the provision of the following services to the same patient: a. evaluation of any relevant laboratory, diagnostic and/or imaging investigations; and b. all discussion or advice, whether by telephone or otherwise, involving the patient, staff, patient's relative(s) or patient's representative related to the oral chemotharapy for a period of twenty-one (21) days following initiation of the agent(s).
When to Use
- Use G388 when initiating high-toxicity oral chemotherapy agents like imatinib or capecitabine that require active monitoring for immediate adverse reactions.
- Use this code to capture the 21-day period of follow-up care, including all telephone advice and laboratory review related to the initiation of the oral agent.
Common Pitfalls
- Billing G388 in the same month as G382 will trigger an automatic rejection; ensure you are not claiming both for the same patient in the same billing cycle.
- Failing to document the specific 24-hour availability window post-initiation is a frequent audit trigger for this code.
Billing Tips
- Ensure the 21-day follow-up period is clearly tracked, as all subsequent consultations or telephone calls regarding the chemotherapy are considered included in the G388 fee.
Effective: April 1, 2026
J. Diagnostic and Therapeutic Procedures
DIAGNOSTIC AND THERAPEUTIC PROCEDURES
ManagementFee
Diagnostic and Therapeutic Procedures
In addition to standard medical record requirements as per , the physician should document the initiation of the specific oral chemotherapy agent, their availability for 24 hours post-initiation, and any included follow-up activities such as evaluation of investigations and discussions with the patient or team.
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